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Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management - Pergolizzi - 2020 - Journal of Clinical Pharmacy and Therapeutics - Wiley Online Library

Approximately 10-15% of patients demonstrate enhanced sensitivity, achieving therapeutic effects at doses below 5 mg daily, while 5-10% appear to be poor responders requiring doses above 10 mg daily for optimal results [4]

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