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For instance, FBXW7 employs K63 chains to modify XRCC4, enhancing the accuracy of non-homologous end joining (NHEJ) repair [5]

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The downstream effects show up in ways most Charleston residents recognize immediately: Afternoon energy crashes followed by a wired-but-tired feeling at night Increased belly fat and sugar cravings that complicate weight management Disrupted sleep architecture, with less deep and restful sleep Elevated blood sugar, insulin resistance, and rising inflammatory responses Low mood, poor mental clarity, and reduced emotional resilience You may have heard the term adrenal fatigue used to describe this pattern