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[DOI] [PubMed] [Google Scholar] 159.Cao P, Marek P, Noor H, Patsalo V, Tu LH, Wang H, Abedini A and Raleigh DP, Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity, FEBS Lett, 2013, 587, 1106–1118

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Although HDACi face challenges in clinical application, such as poor water solubility, rapid clearance, and high systemic toxicity, their effectiveness in inhibiting tumor growth and metastasis has been supported by numerous studies (111)