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Furthermore, stabilization of NRF2 in cancer cells harboring oncogenic RAS induces genes encoding stress-responsive enzymes, including GPXs, NAD(P)H:quinone oxidoreductase-1 (NQO1), glutamate-cysteine ligase (GCL), GR, heme oxygenase-1 (HO-1), and glutathione S-transferase (GST), some of which are directly involved in cellular glutathione biosynthesis and ROS detoxification 22,23,24

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Only two post-stop observations exist : a rat ACL study where the benefit was gone about seven weeks after the last injection, and a six-active human scalp study with no washout design

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