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Tripeptides such as GHK-Cu have an established safety record in topical and cosmetic applications, showing low cytotoxicity and reduced skin irritation compared with other copper compounds, and acceptable tolerability in clinical cosmetic studies 23 , 74 , 93

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Several transition metal ions can catalyze Fenton and Fenton-like reactions to produce hydroxyl radicals (∙OH) and kill cancer cells in the TME