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Recently, extracellular matrix derived from mesenchymal stem cells were shown to maintain re-differentiation potential of human chondrocytes ( Conclusion In vitro expanding human chondrocytes to a number that is required by the ACI results in the generation of senescent cells

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This is in line with the higher expression of the major mitochondrial fission GTPase, dynamin-related protein 1 (DRP1) 76 (Fig