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10.2147/ijn.S45031 109 ZhangY.YangX.WangS.SongS.YangX

Copper

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As an example, Liu and co-workers designed a Fe 2+ -contained and PEG-modified nanocatalyst reacting with overexpressed H 2 O 2 to generate sufficient •OH, which is able to kill tumor cells ( 2 nanoparticles encapsulated with Cu-ferrocene for oxidating GSH, named CCF ( 2+ , which released from decomposed CCF in an acidic environment, triggered GSH exhaustion (Figure 5A) and Cu + -mediated Fenton-like reaction, avoiding the potential •OH elimination