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Key Takeaways Humana covers Wegovy for weight loss only on select Medicare Advantage and commercial plans, not traditional Medicare Part D, with coverage requiring BMI ≥30 (or ≥27 with comorbidities), prior authorization, and documented lifestyle intervention failure The majority of Humana Medicare Advantage plans exclude Wegovy entirely under the Medicare Part D anti-obesity drug exclusion, which remains in effect through 2026 despite ongoing legislative efforts When Humana denies coverage, compounded semaglutide costs $297-$347/month through platforms like FormBlends, compared to Wegovy's $1,349 list price, and does not require insurance approval Prior authorization approval rates for Wegovy on Humana commercial plans average 43% on first submission, with denials most commonly citing insufficient documentation of lifestyle intervention or BMI documentation errors The short answer Humana's Wegovy coverage depends entirely on your specific plan type