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Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WL—indicating potential weight-independent effects of GCG on hepatic steatosis [40]

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[DOI] [PubMed] [Google Scholar] McCullagh M