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For example, in 2021, a three-month double-blind trial involving 85 people with dementia demonstrated a "clear correlation" between high spermidine intake (3.3mg per day) and improved performance on the Mini-Mental State Examination.15 Another study, published the following year, points to a potential mechanism of action: that spermidine's role as an autophagy activator may help counter Alzheimer's dementia–related neuroinflammation and degrade amyloid beta, a brain protein associated with Alzheimer's disease.16 Also worth noting is a 12-month trial with 100 subjects that demonstrated "no significant changes" in memory performance with 0.9mg of spermidine per day