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Intranasal administration of resveratrol nanoparticle formulation has been shown to reduce retinal ganglion cell loss in a multiple sclerosis model of mouse [153]

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Lipoic acid prevented NOX-induced superoxide production in a rat model of cerebral ischemia and limited infarct volume and neurological deficiencies through upregulating the insulin-phosphatidylinositide-3 kinase (PI3K)-protein kinase B (PKB/Akt) signaling pathway (40)

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