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Antiviral therapies, such as nucleos(t)ide analogs and interferons, can control viral replication but rarely cure the infection due to the persistence of HBV covalently closed circular DNA (cccDNA) ( While HBV alone can drive CHB, cirrhosis, and HCC, concurrent alcohol use accelerates liver damage, increases HBV persistence, and raises the risk of malignancy

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It may take as long as three to four weeks for the former group to experience said signs