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If your presentation is straightforward insulin-resistant PCOS without a particularly elevated inflammatory load, the inositol-and-diet foundation is doing the heavy lifting and NAC's marginal contribution is harder to justify against its evidence base

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hepatic copper correlated with AST and bilirubin, but not with TPN duration (median 1.9 years, range 0.3-18.0) or serum copper, and the overload "occurs through chronic cholestasis