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2–6 The next generation of GLP-1 receptor agonists has a dual action mechanism, targeting both GLP-1 and glucose-dependent insulinotropic peptide (GIP) receptors, and shows greater efficacy for weight loss

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The addition of glucagon receptor agonism does not appear to introduce fundamentally new safety concerns beyond those observed with GLP-1 receptor agonists, although the glucagon component modulates the profile in ways that require careful clinical monitoring