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This involvement in nucleotide synthesis contributes to the maintenance of genetic material in nerve cells (6).Additionally, PLP plays a role in homocysteine metabolism, catalyzing the reaction that forms 5,10-methylene-THF, needed for the methylation of homocysteine to methionine,which also depends upon B2, B6, B9 and B12 vitamins (6, 11, 57, 58) ( Figure 5 )

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A safety-first approach matters because: Supplements aren’t regulated the same way as prescription medications, and dosages/quality can vary