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gastric ulcers, duodenal ulcers, and mucosal erosion where direct local peptide delivery to the damaged tissue is the therapeutic goal • Inflammatory bowel conditions: Crohn's disease and ulcerative colitis support, where VEGF-mediated mucosal angiogenesis and anti-inflammatory effects have been investigated • Leaky gut and intestinal hyperpermeability: tight junction restoration and mucosal integrity support in patients with compromised gut barrier function • Gastroparesis: pro-motility effects via vagal cholinergic pathways investigated in preclinical models of delayed gastric emptying