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Note that such counteraction via BPC 157 therapy may be important as blood–brain barrier injury, increased capillary permeability in the brain, increased extracellular fluid, cerebral white matter edema, and, finally, increased intracranial pressure during intra-abdominal hypertension have all been postulated to relate to the release of these cytokines [81,82,83]

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Although APAP is considered safe under therapeutic doses, its overdose can induce severe liver toxicity and even death (Yoon et al., 2016)