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Glutathione Synthetase - an overview | ScienceDirect Topics

ALP is a key phosphomonoesterase during osteogenic differentiation especially biomineralization, which can catalyze the dephosphorylation of phosphate monoester substrates (DNA, RNA, proteins, and alkaloids) and the production of inorganic phosphate, providing abundant PO 4 3− for the formation of mineralized nodules 41

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Notably, intestinal tryptophan metabolism shortcomings (AhR signaling deficiencies) and poor butyrate consumption are especially important