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[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors α and β, which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

EMS

Size:1 fl. oz.

(Source 2) Tomatoes, and other nightshade vegetables, originated in Central and South America