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GABA Neurotransmission In the neural networks of the brain, GABA functions as the primary inhibitory neurotransmitter, acting on both ionotropic (GABA A R, or GABRA) and metabotropic (GABA B R, or GABRB) receptors, both of which are widely distributed in the cerebral cortex, hippocampus, basal ganglia, thalamus, cerebellum, and brainstem [91]