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Frederick et al., 2016), reduces the mitochondrial unfolded protein response (Mendelsohn and Larrick, 2017), disrupts ATP biosynthesis, decreases the ability to pump calcium against the intracellular gradient (Camandola and Mattson, 2011), disrupts calcium homeostasis, increases excitotoxicity (Rzheshevsky, 2014) and has deleterious effects on muscle health (Goody and Henry, 2018)