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Vitamin B12 (cobalamin) is a water-soluble vitamin essential for neurological function, DNA synthesis, and red blood cell formation

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However, in the severe phase of the disease, possibly as a consequence of the prolonged bioenergetic deficits and the high oxidative stress derived from these alterations, there is an increase in amyloid plaques (75) that activate apoptotic pathways, aberrant mitochondrial biogenesis and altered mitophagy resulting in neuronal death (76)