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In a previous study, the long-acting GHRH analog CJC-1295 was shown to promote an increase in GH and IGF-1 levels in sera of healthy young adult men one week after administration, without affecting the pulsatility of GH secretion [8]

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This highlights the need for improved methods to measure and quantify oxidative stress including male oxidative stress infertility biomarkers such as 8-hydroxy-2′-deoxyguanosine, the use of omics studies, and DNA methylation panels [76,77]