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163 , 164 Induction of the KP is associated with significant immunomodulatory changes, for which two non-mutually exclusive mechanisms have been proposed

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A post-mortem study of human pancreases demonstrated proliferative effects in those cases with GLP-1RA use, which were manifest by an increased mass of the pancreas along with increased frequency of PanIN1 and PanIN2 lesions compared to diabetes controls 23